LNEYA Chillers
Pharma Process Temperature Control Units
Use existing thermal energy (such as steam, cooling water or ultra-low temperature liquid) to integrate into the single-fluid system or secondary tempering system used to control the temperature of process equipment, non-contact temperature control in the reaction vessel jacket that constitutes but heat transfer liquid system.
Advantages of using a single fluid heat transfer temperature control system:
A. Users can get a closed and repeatable temperature control in a wide temperature range, which can realize temperature control from -120 degrees to 300 degrees;
B. Avoid the replacement of traditional equipment and facilities and the need for jacket maintenance; the smaller fluid volume also ensures the rapid response of the control loop and the thermal response delay is small;
C. Built-in electric heating and heat transfer oil auxiliary system, which can automatically turn on the auxiliary heating system according to the demand, and reduce the pressure of steam use;
D. It can achieve the purpose of saving energy through fast operation and accurate matching of each heat demand;
E. Control the temperature of the entire reaction process through accurate and fast calculations, and perform rapid response control for exothermic and endothermic reactions in the entire reaction process;
F. Standardized interfaces are reserved, and cold and heat source heat exchange modules can be added according to actual needs;
G. You can choose to control the temperature of the reaction process and the temperature of the single fluid, and the temperature difference between the temperature of the reaction process and the temperature of the heat conduction single fluid can be set and controlled;
H. Formula management and production process records can be carried out.
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DCS Integrated Temperature Control System
Realize the automation and serialization of pharmaceutical production
Through the application of advanced pharmaceutical equipment and its automatic control technology, the technical level of the product has been improved, the product quality and output have been greatly improved, and the market competitiveness of the product has been improved.
The design of this solution is based on the advanced process control system SIMATIC PCS 7. It refers to the advanced concept of real-time release detection in the new version of GMP drug production quality management regulations and the implementation of product life cycle proposed by the International Society of Pharmaceutical Engineering (ISPE), and establishes the quality of the whole process of pharmaceutical production. The monitoring system realizes the quality management of the whole production process from raw materials to finished products, makes the pharmaceutical production process digital and standardized, and has data traceability and early warning functions, and comprehensively improves the quality control level of pharmaceutical production.
LNEYA has a complete process research department, design technology department, engineering implementation department and professional engineering installation department, and a professional engineering service team. The employees have many years of experience in pharmaceutical industry design and construction. Our design and implementation personnel have Participated in the completion of more than 100 pharmaceutical automatic control projects, with sufficient design and implementation experience, can provide users with professional engineering services.
According to the process requirements of pharmaceutical batch production, establish an appropriate production model and strengthen the management of pharmaceutical batches. Through the management modules such as production plan designation, production plan release and production plan tracking for production batches, the batch management of pharmaceutical production is realized.
Through the application of computer management systems and automatic control systems that comply with GMP specifications, fully automatic collection and monitoring of production data can be realized, and efficient, accurate and complete data collection and analysis can be carried out through computer systems, avoiding the traditional The manual recording method is prone to problems such as lagging, missing and errors in production data.
The traceability of pharmaceutical production data is a necessary content for the certification of the pharmaceutical industry such as GMP and FDA. Applying the pharmaceutical production automation control system and pharmaceutical intelligent production quality information management system software, the batch, product name, time, Real-time, complete, and accurate comprehensive records of pharmaceutical production data such as production equipment numbers and operators, and the process of reverse retrieval of production data can restore the production status of each production link, enabling producers to analyze the causes of product quality defects. At the same time, through the data traceability function, producers can clearly understand the actual production status, and provide data basis for improving production.
Applying the automation of the production process and the informatization of the management system to the pharmaceutical production process has a significant energy-saving effect, and at the same time reduces the intermediate links of pharmaceutical production and eliminates the waste of products in the production flow link.
Realize real-time monitoring and regulation of key process parameters and quality, clarify key process control parameters and product characteristics, and then realize production process optimization and product quality improvement.
Temperature Process Control Principle (Control Reaction Kettle Material Temperature)
A specially designed lag estimator (model-free self-building tree algorithm) generates a dynamic signal yc(t) instead of the process variable y(t) as a feedback signal. Generate an e(t) signal to the controller, so that the controller does not have a large hysteresis in predicting the control effect, so that the controller can always generate an appropriate control signal. That is to say, this dynamic signal yc(t) can keep the feedback loop working normally even if there is a large lag.
While using general PID to control a process with a significant time lag, the controller output is not properly obtained during the lag time. The feedback signal keeps growing, which leads to a large overshoot of the system response and even makes the system out of control.
One TCU can control 2-20 reaction kettles of different sizes and materials. The TCU temperature control unit is a special device for precise temperature control in the chemical and pharmaceutical industry to meet the temperature control of batch reactors or continuous process. Heating and cooling, constant temperature system.
TCU case application
◆ Fully automatic TCU temperature control system
◆ DCS system design and implementation
◆ Secondary design of automation control system in pharmaceutical workshop;
◆ Selection and supply of equipment, valves and instruments for the automation control system;
◆ Supply and installation of cables, bridges, air pipes and protective pipes related to automation control;
◆ Wiring of instruments, valves, control cabinets and valve island boxes of the automation control system;
◆ Automatic control system software development, control program writing and debugging;
◆ Responsible for single instrument adjustment, automatic control system linkage debugging, qualified acceptance and delivery;
◆ Responsible for technical training and after-sales service in daily use and maintenance for users;
◆ Responsible for the preparation of all equipment, material lists and budgets of the control system;
◆ Responsible for providing the I/O points of the entire system;
◆ Design of central control room for automation control;
◆ Process pipeline design and construction;
◆ Supply and installation of cold water system;
Tell us the temperature control effect you want to achieve, we will customize the corresponding plan for you
